LY364947,LY47-02/10/50

产品信息

TGF-β家族成员广泛存在于从果蝇到人多种生物的 各种组织中，对正常细胞、癌变细胞都有着显著作用。TGF-β除了影响细胞的增殖、分化，还在胚胎发育、胞外基质形成、 骨的形成和重建等方面起着重要作用。

LY364947, A Selective inhibitor of TGF-beta type-I receptor (IC50 59 nM for TGF-beta RI vs. 400 nM for TGF-beta RII). [3-(Pyridin-2-yl)-4-(4-quinonyl)]-1H-pyrazole

Ref: Sawyer et al. Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-μ type I receptor kinase domain. J. Med. Chem. 46 3953, 2003.

Purity:Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.

Biological Activity:
In a cell-based assay measuring the activation of a SMAD reporter gene, this compound gives IC50 around 100-200 nM.

重庆市华雅干细胞技术有限公司