BIO（GSK-3β inhibitor），糖原合成酶激酶抑制剂，BIO-005/025/100

产品信息

Wnt信号通路是一个复杂的蛋白质作用网络，其功能zui常见于胚胎发育和癌症，但也参与成年动物的正常生理过程。Wnt信号通路包括许多可调控Wnt信号分子合成的蛋白质，它们与靶细胞上的受体相互作用，而靶细胞的生理反应则来源于细胞和胞外Wnt配体的相互作用。

BIO (6-bromoindirubin-3'-oxime):
a specific GSK3 kinase inhibitor. Inhibition of GSK3-beta results in activation of the canonical WNT pathway leading to the translocation of beta-catenin to the nucleus.

This chemical compound from StemRD is 98.5% pure (HPLC). In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives EC50 of 5.0 micromolar.

Purity:
Greater than 98.5% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.

Biological Activity:
In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives EC50 of 5.0 micromolar.

重庆市华雅干细胞技术有限公司