GDC-0941（PI3 Kinase Inhibitor）,（PI3 激酶抑制剂）

产品信息

Hedgehog（Hh） 信号通路调节胚胎发育和成体许多组织器官干细胞的自我更新与增殖。然而，那些在正常发育过程中受到Hh信号通路调节的组织器官，在该信号通路异常时常常发 生肿瘤。这些肿瘤包括肝癌、神经胶质瘤、基底细胞癌、横纹肌肉瘤、胰腺癌、小细胞肺癌、胃癌、结肠癌、前列腺癌、黑色素瘤和多发性骨髓瘤等。

GDC-0941 is a potent inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 3 nM, 33 nM, 3 nM and 75 nM, respectively. Administration of GDC-0941 in animals displays significant inhibitory effect against established human cancer xenografts. It is currently in clinical trials.

PI3K inhibitors have been used for differentiation of pluripotent stem cells

Purity:
Greater than 99% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.

Biological Activity:
Not determined.

重庆市华雅干细胞技术有限公司