Dorsomorphin，Dor-02/10/50

产品信息

TGF-β家族成员广泛存在于从果蝇到人多种生物的 各种组织中，对正常细胞、癌变细胞都有着显著作用。TGF-β除了影响细胞的增殖、分化，还在胚胎发育、胞外基质形成、 骨的形成和重建等方面起着重要作用。

Dorsomorphin:
A selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK-2, ALK-3 and ALK-6). Also inhibits AMP-activated protein kinase (AMPK). 6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE

Ref: Yu et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat. Chem. Biol. 4 33, 2008.

Purity:
Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.

Biological Activity:
Not determined.

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