LDN-193189

产品信息

TGF-β家族成员广泛存在于从果蝇到人多种生物的 各种组织中，对正常细胞、癌变细胞都有着显著作用。TGF-β除了影响细胞的增殖、分化，还在胚胎发育、胞外基质形成、 骨的形成和重建等方面起着重要作用。

LDN-193189:
A selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK-2 and ALK-3). Only weakly inhibits ALK-4,-5, and -7.
4-[6-(4-Piperazin-1-yl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline

Ref: Cuny, G.D., et al. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett 18: 4388-92, 2008.

Purity:
Greater than 98% as determined by LC/MS analysis.

Biological Activity:
Not Determined

重庆市华雅干细胞技术有限公司