Ras 同源基因-Rho相关螺旋卷曲蛋白激酶(Ras homolog gene/a Rho-associated coiled coil-forming protein kinase,Rho-ROCK)信号途径是中枢神经系统中普遍存在的一条通路,是介导抑制性信号阻断中枢神经细胞再生的重要途径。
Y-27632: (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridine-4-yl) cyclohexane-carboxamid-2HCl, is a Rho-associated kinase (ROCK) inhibitor. Y-27632 has been shown to prevent apoptosis as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their pluripotency.
Purity: Greater than 99% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity: Tested active for culturing human iPS cells in serum-free medium on Matrigel coated plates.