Thiazovivin; N-苄基-2-（嘧啶-4-基氨基）噻唑-4-甲酰胺 Thia-01/05/25

产品信息

Ras 同源基因-Rho相关螺旋卷曲蛋白激酶(Ras homolog gene/a Rho-associated coiled coil-forming protein kinase,Rho-ROCK)信号途径是中枢神经系统中普遍存在的一条通路，是介导抑制性信号阻断中枢神经细胞再生的重要途径。

Thiazovivin, N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide, is a selective inhibitor of Rho-associated kinase (ROCK). It protects human ES cells from death in the absence of ECM by regulating E-cadherin mediated cell-cell interaction. Thiazovivin, in combination with inhibitors of the TGF-beta receptor and the MEK kinases, improves reprogramming efficiency dramatically.

Purity:
Greater than 99% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.

Biological Activity:
Tested active for culturing human iPS cells in serum-free medium on Matrigel coated plates.

重庆市华雅干细胞技术有限公司