BMP-2,human 人骨形态发生蛋白2 BMP-2-005/025/100

产品信息

转化生长因子β(transforming growth factor)家族由一类结构、功能相关的多肽生长因子 亚家族组成，其中包括TGF-β、活化素(activin)、骨形态发生蛋白(BMP)、生长分化因子( GDF)等。TGF-β除了影响细胞的增殖、分化，还在胚胎发育、胞外基质形成、 骨的形成和重建等方面起着重要作用。TGF-β家族成员广泛存在于从果蝇到人多种生物的 各种组织中，对正常细胞、癌变细胞都有着显著作用。

Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins.

BMP-2 like other bone morphogenetic proteins,plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine-cytokine receptor interaction. It is involved also in cardiac cell differentiation and epithelial to mesenchymal transition.

BMP-2 and BMP-7 are osteoinductive BMPs: they have been demonstrated to potently induce osteoblast differentiation in a variety of cell types.

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