Recombinant Human GM-CSF

Catalog Number:

300-03

Synonyms:

Granulocyte-Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, Pluripoietin-α

         GM-CSF是，刺激中性粒细胞和巨噬细胞的发展造血生长因子，并促进早期红细胞巨核细胞和嗜酸性祖细胞的增殖和发展。它产生于血管内皮细胞，单核细胞，成纤维细胞和T-淋巴细胞。GM-CSF抑制中性粒细胞迁移和增强了成熟的zui终细胞的功能活性。人和鼠分子是物种特异性，并表现出无交叉物种反应性。重组人GM-CSF是14.6 kDa的球状蛋白包含128个氨基酸，含有两个分子内二硫键和两个潜在的N-联糖基化位点。

Description:

GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages, and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant Human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids, containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites.

AA Sequence:

MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQE

Source:

E.coli

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.

Cross Reactivity:

Human, Bacteria, Mouse, Leech, Pig, Human + Mouse

Animal Free Recombinant Protein AF-300-03 AF-300-03-20 Human GM-CSF 20ug Standard
Animal Free Recombinant Protein AF-300-03 AF-300-03-50 Human GM-CSF 50ug Bulk
Animal Free Recombinant Protein AF-300-03 AF-300-03-100 Human GM-CSF 100ug Bulk
Animal Free Recombinant Protein AF-300-03 AF-300-03-250 Human GM-CSF 250ug Bulk
Animal Free Recombinant Protein AF-300-03 AF-300-03-500 Human GM-CSF 500ug Bulk
Animal Free Recombinant Protein AF-300-03 AF-300-03-1000 Human GM-CSF 1000ug Bulk